Key result
Intravenous sodium nitroprusside achieved an 80% shock-reversal rate compared to 0% with saline in a rabbit model of massive pulmonary embolism with circulatory shock.
Why the study?
Does intravenous sodium nitroprusside improve hemodynamics and reverse circulatory shock in a rabbit model of massive pulmonary embolism?
Population
Rabbit model of acute massive pulmonary embolism with associated circulatory shock induced using autologous…
Comparison
Sodium nitroprusside administered intravenously… vs Model group receiving an equal volume of saline…
Design
Preclinical, Rabbits were randomly assigned
Authors
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Does not support clinical use in massive PE shock; leaves open human translation of nitroprusside.
RCT
randomly assigned
Does intravenous sodium nitroprusside improve hemodynamics and reverse circulatory shock in a rabbit model of massive pulmonary embolism?
Absolute Event Rate: 80% vs 0%
Intravenous sodium nitroprusside partially reverses acute circulatory failure and improves hemodynamics in a rabbit model of massive pulmonary embolism, likely by reducing pulmonary vasospasm in nonembolic regions.
Yu et al. (2018) conducted an RCT in acute massive pulmonary embolism with associated circulatory shock. Sodium nitroprusside vs. Saline intravenously (model group) and sham operation was evaluated on shock-reversal rate. Intravenous sodium nitroprusside achieved an 80% shock-reversal rate compared to 0% with saline in a rabbit model of massive pulmonary embolism with circulatory shock.
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