lymphoma in a haemophiliac negative for HIV.Serum samples from 1983 and 1984 examined retrospectively also failed to show this antibody.All serum samples were negative for antibody to human T cell lymphotropic virus type I.Histologically similar extranodal lymphomas have been reported in homosexual men negative for antibody to HIV but with inverted ratios of T helper to suppressor cells.4The aetiology of the lymphomas in such patients is not clear.Congenital and other acquired immune defects are also associated with lymphomas.We previously reported abnormal cell mediated immunity in haemophiliacs with factor VIII concentrate and negative for HIV antibody.5Such defects may have contributed to the pathogenesis of the tumour in our patient.
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Mossman et al. (1987) studied this question.
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