Four patients with the syndrome of gonadotropin-producing bronchogenic carcinoma were studied. Each patient had gynecomastia and high titers of gonadotropin in the blood and/or urine. At postmortemthe lung tumor contained large amounts of gonadotropin. None of the patients had any evidence of a testicular tumor. Since there is a predominance of a characteristic cell type associated with some of the other humoral syndromes caused by lung cancer, it was thought useful to describe the histologic findings of the individual tumors. The cell types of the primary lung tumors included well-differentiated epidermoid carcinoma with keratin formation and intercellular bridges, poorly differentiated epidermoid carcinoma, oat cell carcinoma, and bronchiolar adenocarcinoma arising in an area of scarring. These cases, when combined with those which have already been reported, demonstrate that a wide variety of lung cancers are capable of secreting gonadotropin.
No takes yet. Share an insight, caveat, or question.
Cottrell et al. (1969) studied this question.