Dextran-Induced Pulmonary Edema in Patients with Sudden Deafness

OBJECTIVE: Pulmonary complication in cases of sudden deafness after dextran treatment is rarely reported. This study discusses the management of two cases and reviews the current literature. PATIENTS: Two (1%) of 204 patients with sudden deafness patients had fever, cough, and dyspnea after intravenous dextran infusion. Pulmonary edema was diagnosed after chest radiographic examination. RESULTS: After interruption of dextran, subsequent supportive treatment relieved chest discomfort and fever without any sequelae. The results of chest radiograph and laboratory studies, including hemogram, renal function, and arterial blood oxygen saturation, were normal. CONCLUSIONS: Patients receiving dextran treatment should have their clinical symptoms, renal function, chest radiographs, hemogram, and coagulation profiles monitored. If fever, bleeding, cough, or dyspnea occurs during treatment, dextran must be immediately stopped. Subsequent treatment should focus on dextran clearance to prevent further cascade complications.