Key result
Analysis of 732 aorto-coronary vein grafts revealed early endothelial lesions causing thrombosis, whereas longer survival was associated with intimal hyperplasia and atherosclerotic plaques.
Population
348 patients with implanted aorto-coronary vein grafts, contributing a total of 732 grafts.
Design
Cohort
Follow-up
Various time intervals (divided into early and late)
Authors
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Endothelial injury drives early vein graft thrombosis while hyperplasia drives late failure; leaves open targeted prevention trials.
Observational (n=348)
Histopathological analysis of aorto-coronary vein grafts confirms that early graft failure is primarily driven by endothelial injury and thrombosis, while late failure is due to intimal hyperplasia and atherosclerosis.
Tatić et al. (2004) conducted an observational in Implanted aorto-coronary vein grafts (n=348). Aorto-coronary vein grafts was evaluated on Morphological changes in aorto-coronary vein grafts. Analysis of 732 aorto-coronary vein grafts revealed early endothelial lesions causing thrombosis, whereas longer survival was associated with intimal hyperplasia and atherosclerotic plaques.
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