Key result
Computational fluid dynamics modeling was used to investigate the effects of velocity waveform instabilities and computational mesh variations on wall shear stresses in intracranial aneurysms.
Demonstrates the use of computational fluid dynamics for patient-specific modeling of blood flow and wall shear stress in intracranial aneurysms.
CFD-derived wall shear stress estimates in aneurysms may vary with inputs; leaves open standardization and validation before clinical use.
The visualisation of blood flow dynamics in intracranial aneurysm using computational fluid dynamics is an example of personalised medicine based on biomedical image analysis. A small percentage of these aneurysms rupture. Blood flow dynamics is thought to play an important role in the rupture process by exerting Wall Shear Stresses (WSS) on the endothelial cells. In this study, the effects of instabilities in the velocity waveform in the parent artery of an aneurysm of the Internal Carotid Artery (ICA) and variations of the computational mesh are investigated with respect to WSS at the aneurysm wall.
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Karmonik et al. (2009) studied Intracranial aneurysm. Computational fluid dynamics modelling was evaluated on Wall Shear Stresses (WSS) at the aneurysm wall. Computational fluid dynamics modeling was used to investigate the effects of velocity waveform instabilities and computational mesh variations on wall shear stresses in intracranial aneurysms.
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