Key result
Patients with lacunar infarctions had significantly more impaired flow-mediated dilatation (0.4%) compared to patients with similar risk factors (3.8%) and healthy controls (7.9%) (P<=0.01).
Why the study?
Do patients with lacunar infarctions have more impaired systemic endothelial function and atherosclerotic changes compared to patients with similar risk factors and healthy controls?
Case-Control (n=62)
Do patients with lacunar infarctions have more impaired systemic endothelial function and atherosclerotic changes compared to patients with similar risk factors and healthy controls?
Absolute Event Rate: 0.4% vs 3.8%
p-value: p=<=0.01
Patients with lacunar infarctions exhibit additional systemic endothelial impairment beyond what is expected for their level of atherosclerosis and risk factors.
Lacunar infarctions associate with greater endothelial dysfunction than risk factors predict; hypothesis-generating and leaves open causality or therapeutic targets.
OBJECTIVES: To evaluate systemic endothelial function and atherosclerotic changes in patients with lacunar infarctions (LI) we examined flow-mediated dilatation (FMD) and intima-media thickness (IMT) and compared them to patients with similar risk factors (SR) and healthy controls. METHODS: FMD and IMT were investigated in patients with LI (20 patients, aged 60.9 +/- 7.3 years), 21 age- and gender-matched patients with SR and 21 healthy controls. RESULTS: FMD was more impaired in patients with LI (0.4% +/- 5.0%) compared to patients with SR (3.8% +/- 4.8%) and healthy controls (7.9% +/- 6.0%) (P < or = 0.01), whereas IMT was similarly thickened in both groups of patients. CONCLUSIONS: We found that patients with LI have a diminished FMD, but a similar IMT, compared to patients with SR. Our results reveal that for a given level of atherosclerosis patients with LI have additional endothelial impairment.
No takes yet. Share an insight, caveat, or question.
Oblak et al. (2006) conducted a case-control in Lacunar infarctions (n=62). Lacunar infarctions vs. Patients with similar risk factors and healthy controls was evaluated on Flow-mediated dilatation (FMD) (p=<=0.01). Patients with lacunar infarctions had significantly more impaired flow-mediated dilatation (0.4%) compared to patients with similar risk factors (3.8%) and healthy controls (7.9%) (P<=0.01).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: