Permanent Left Bundle Branch Area DF‐4 Defibrillator Lead Implantation—Feasibility, Procedural Caveats, Safety, and Follow‐Up

INTRODUCTION: Permanent implantation of a DF-4 implantable cardiac defibrillator (ICD) lead in the left bundle branch area (LBBA-ICD) is the next paradigm in amalgamating cardiac resynchronization therapy (CRT) and defibrillation. We systematically investigated feasibility/success rate, procedural caveats, and complications associated with a permanent DF-4 LBBA ICD implant and pertinent data at short-term follow-up. METHODS: We prospectively attempted implantation of 7 Fr Durata (Abbott, Chicago, IL, USA) single coil DF-4 ICD lead at the LBBA using a fixed-curve non-deflectable CPS locator delivery sheath. Standard criteria defined LBBA capture. Relevant sensing/pacing, defibrillation, radiographic, and echocardiographic parameters testing were recorded at implant, discharge and 5-month follow-up. RESULTS: We enrolled 12 consecutive cardiac device-naïve patients (median age 67.5 years, male 91.7%, median LVEF 30%, median septal thickness 9 mm, median QRS duration 140 ms, class I CRT indication 58.3%, primary prevention ICD indication 75%). Minor complications (two transeptal perforations and one micro-dislodgment) were noted in 3/12 (25%) patients. Successful permanent LBBA ICD implant with adequate sensing/pacing was achieved in 9/12 (75%) subjects. Sustained ventricular fibrillation (VF) was inducible in 7/9 patients with successful implants with effective sensing and defibrillation in all. Follow-up device-related and echocardiographic parameters were similar at discharge and 5-month follow-up. CONCLUSION: Permanent DF-4 LBBA ICD implant is feasible and successful in 75% of patients with an indication for ICD. With dedicated toolkits, higher volumes, and an obligate learning curve, the higher-than-expected frequency (25%) of minor complications may be ameliorated. Short-term data regarding lead and selected RV parameters remained favorable.