Key result
Quetiapine treatment for an acute manic episode induced a junctional rhythm in a 65-year-old male, which resolved upon discontinuation of the medication.
Case Report (n=1)
Quetiapine use can be associated with reversible junctional rhythm, highlighting a potential arrhythmogenic side effect of new antipsychotics.
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Quetiapine may cause reversible junctional rhythm; this case leaves open questions of incidence and monitoring needs.
The cardiovascular side effects of older antidepressants and neurolepts are well known. These drugs inhibit the cardiac Na+, Ca2+, and K+ channels often leading to life-threatening arrhythmia. Selective serotonin receptor inhibitor antidepressants and new antipsychotics were introduced to overcome the toxicity of older generation drugs. These drugs have gained popularity owing to their fewer side-effect profiles. However, several case reports have revealed the arrhythmogenic effect of these drugs as well as orthostatic hypotension, especially in those receiving cardiac medications. We report a case of a 65-year-old male who experienced junctional rhythm during the treatment of his acute manic episode with quetiapine and returned to normal sinus rhythm after discontinuing the medication.
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Kulkarni et al. (2018) conducted a case report in Acute manic episode (n=1). Quetiapine was evaluated on Junctional rhythm. Quetiapine treatment for an acute manic episode induced a junctional rhythm in a 65-year-old male, which resolved upon discontinuation of the medication.
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