Quetiapine, a commonly prescribed second-generation antipsychotic, may be associated with acquired QTc prolongation and subsequent Torsades de Pointes.
May cause QTc prolongation and TdP; case report leaves open comparative torsadogenic risk.
Article AbstractBecause this piece does not have an abstract, we have provided for your benefit the first 3 sentences of the full text.Quetiapine is a commonly prescribed second-generation antipsychotic with a wide range of uses in psychiatry. Compared to first-generation high-potency antipsychotics such as thioridazine and high-dose intravenous haloperidol, medications in the newer second-generation antipsychotic class (of which quetiapine belongs) are thought to have a lower risk of prolonging the corrected QT (QTc) interval, torsades de pointes, and sudden death. Among the second-generation antipsychotics of its class, quetiapine is known to prolong the QTc interval in modest levels and less so than ziprasidone and sertindole.
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Giancaterino et al. (2017) studied this question.
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