Key result
Perfused whole rat hearts showed fewer signs of histological degeneration at 37°C for prolonged periods compared to incubated isolated right ventricular strips and atria.
Perfused whole rat heart preparations are histologically superior to incubated isolated tissue preparations, maintaining integrity at physiological temperatures for prolonged periods.
Histological evaluation of isolated rat heart preparations has shown that: Incubated isolated right ventricular strips and atria undergo observable degeneration after relatively short periods of time and at temperatures of 27° or higher. The degree of degeneration is a function of: (a) duration of incubation; (b) incubation temperature: and (c) thickness of the soaked preparation. Cardiac degeneration is not prevented by penicillin, streptomycin, polymyxin, chlorte-tracycline, 9-alpha-fluorohydrocortisone, or ouabain in the doses employed. The perfused whole heart is superior to the incubated isolated tissue preparation. The perfused heart shows few signs of degeneration at 37° for prolonged periods.
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Brown et al. (1968) studied Cardiac degeneration in isolated rat heart preparations. Perfused whole heart preparation vs. Incubated isolated right ventricular strips and atria was evaluated on Histological degeneration. Perfused whole rat hearts showed fewer signs of histological degeneration at 37°C for prolonged periods compared to incubated isolated right ventricular strips and atria.
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