January 12, 1977Acta Medica Scandinavica

Factors Modifying Ischemic Injury in the Isolated Rat Heart

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Why the study?

Do factors such as tachycardia, noradrenaline, GIK, or beta-blockade modify ischemic injury in an isolated rat heart model?

Population

Isolated working rat heart model with reduced coronary flow via an aortic ball valve

Comparison

Exposure to high heart rate, noradrenaline… vs Control isolated rat hearts

Design

Preclinical

Authors

AWAnders WaldenströmHeart Failure & Transplant ÅHÅke C. HjalmarsonSahlgrenska University Hospital

Discussion

Member takes

Implication

In an isolated rat heart model of ischemia, tachycardia, noradrenaline, and palmitate exacerbate injury, while GIK and beta-blockade offer protection.

Structured PICO

Do factors such as tachycardia, noradrenaline, GIK, or beta-blockade modify ischemic injury in an isolated rat heart model?

Population

Isolated working rat heart model with reduced coronary flow via an aortic ball valve

Intervention

Exposure to high heart rate, noradrenaline, acidosis, alkalosis, high afterload, beta-blockade (metoprolol), glucose-insulin-potassium (GIK), palmitate, or methylprednisolone

Comparator

Control isolated rat hearts

Outcome

Ischemic injury determined by mechanical performance, myocardial contents of ATP, creatine phosphate, glycogen and lactate, and leakage of creatine phosphokinase (CK)surrogate

In an isolated rat heart model of ischemia, tachycardia, noradrenaline, and palmitate exacerbate injury, while GIK and beta-blockade offer protection.

Cite This Study

Waldenström et al. (1977) studied this question.

synapsesocial.com/papers/6a859d7a35bc0eada8d5a7f0 https://doi.org/10.1111/j.0954-6820.1977.tb15742.x

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Implication

In an isolated rat heart model of ischemia, tachycardia, noradrenaline, and palmitate exacerbate injury, while GIK and beta-blockade offer protection.