Key result
Fastigial nucleus stimulation significantly reduced myocardial infarct size to 25.16% compared to 41.60% in the control group (p<0.01) and attenuated oxidative damage in rats with acute myocardial infarction.
Why the study?
Does fastigial nucleus stimulation reduce infarct size and oxidative damage in rats undergoing acute myocardial infarction?
Population
40 healthy male Wistar rats undergoing surgically induced acute myocardial infarction via left anterior…
Comparison
Electrical stimulation of the fastigial nucleus… vs AMI without stimulation, sham-operated…
Design
Preclinical, randomly divided into four groups
Follow-up
24 hours
Authors
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Should not change clinical practice; hypothesis-generating for fastigial nucleus stimulation in cardioprotection.
Does fastigial nucleus stimulation reduce infarct size and oxidative damage in rats undergoing acute myocardial infarction?
Absolute Event Rate: 25.16% vs 41.6%
p-value: p=<0.01
Electrical stimulation of the fastigial nucleus reduces myocardial infarct size and oxidative damage in a rat model of acute myocardial infarction.
Wei et al. (2008) studied Acute Myocardial Infarction (n=40). Fastigial nucleus stimulation (FNS) vs. Acute myocardial infarction (AMI) without FNS was evaluated on Myocardial infarct size (% of left ventricular weight) (p=<0.01). Fastigial nucleus stimulation significantly reduced myocardial infarct size to 25.16% compared to 41.60% in the control group (p<0.01) and attenuated oxidative damage in rats with acute myocardial infarction.
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