Key result
Intravenous administration of 5-fluorouracil induced multivessel coronary vasospasm and subsequent Takotsubo cardiomyopathy presenting as severe acute heart failure in a 69-year-old woman.
Case Report (n=1)
No
5-fluorouracil administration can induce multivessel coronary vasospasm and microcirculation disorders, potentially leading to Takotsubo cardiomyopathy and acute heart failure.
Authors
No takes yet. Share an insight, caveat, or question.
Raises awareness for 5-FU cardiotoxicity monitoring; single case leaves open incidence and causality.
Kobayashi et al. (2009) conducted a case report in Takotsubo cardiomyopathy (n=1). 5-fluorouracil was evaluated on Development of acute heart failure and Takotsubo cardiomyopathy. Intravenous administration of 5-fluorouracil induced multivessel coronary vasospasm and subsequent Takotsubo cardiomyopathy presenting as severe acute heart failure in a 69-year-old woman.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: