Key result
Angiotensin II induces DNA damage in kidney cells through an AT1 receptor-mediated activation of NADPH oxidase via PLC, PKC, and calcium signaling, with the Nox4 subunit playing a crucial role.
Population
Kidney cell lines with properties of proximal tubulus cells and isolated perfused mouse kidney
Design
Preclinical
Authors
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May link hypertension to renal carcinogenesis via Nox4; hypothesis-generating for human studies on AT1R inhibition.
Angiotensin II induces DNA damage in kidney cells through an AT1R-mediated pathway involving Nox4, providing a potential mechanistic link between hypertension and renal cancer.
Fazeli et al. (2012) studied Angiotensin II-induced DNA damage. Angiotensin II was evaluated on DNA strand breaks and micronuclei induction. Angiotensin II induces DNA damage in kidney cells through an AT1 receptor-mediated activation of NADPH oxidase via PLC, PKC, and calcium signaling, with the Nox4 subunit playing a crucial role.
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