Key result
ETA binding sites predominated (~80%) on veins and arteries in the chorionic plate, while ETB sites were high (~60-70%) on veins in stem villi and decidual cells, with no significant difference in binding density between normal and pre-eclamptic placentae.
Population
Sections of human placenta from pregnancies complicated by pre-eclampsia and normal term controls
Comparison
In vitro autoradiography using receptor… vs Normal term controls
Design
Preclinical
Authors
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Differential ET receptor distribution in placenta does not differ in pre-eclampsia; leaves open subtype-specific functional roles in foetoplacental flow.
p-value: p=>0.144
Endothelin receptor subtypes ETA and ETB exhibit differential distribution in the human placenta, suggesting a local autocrine or paracrine role in regulating foetoplacental blood flow, though this distribution is unaltered in pre-eclampsia.
Rutherford et al. (1993) studied Normal pregnancy and pre-eclampsia (n=19). Pre-eclampsia vs. Normal term pregnancy was evaluated on Relative density of [125I]-ET-1 binding sites and proportion of ETA to ETB sites (p=>0.144). ETA binding sites predominated (~80%) on veins and arteries in the chorionic plate, while ETB sites were high (~60-70%) on veins in stem villi and decidual cells, with no significant difference in binding density between normal and pre-eclamptic placentae.
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