Key result
Oral nifedipine required fewer doses to achieve targeted blood pressure compared to intravenous hydralazine (1.4 vs 1.7 doses, P=0.008) in pregnant women with severe hypertension.
Why the study?
The quality of evidence regarding the best antihypertensive agent for treating hypertensive emergencies in pregnancy remains poor despite the availability of effective drugs.
Does oral nifedipine reduce the number of doses needed to achieve targeted BP compared to intravenous hydralazine in pregnant women with severe hypertension?
Population
78 pregnant women (≥28 weeks gestation) with severe hypertension
Comparison
Oral nifedipine vs intravenous hydralazine
Design
Open-label parallel randomized controlled trial
Authors
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Comparable efficacy supports oral nifedipine as alternative to IV hydralazine; extends RCT data for severe hypertension in pregnancy.
RCT (n=78)
Open-label
1:1 ratio
Does oral nifedipine reduce the number of doses needed to achieve targeted BP compared to intravenous hydralazine in pregnant women with severe hypertension?
Absolute Event Rate: 1.4% vs 1.7%
p-value: p=0.008
Oral nifedipine required fewer doses to achieve target blood pressure compared to intravenous hydralazine in pregnant women with severe hypertension, with similar time to control and safety profiles.
Adebayo et al. (2020) conducted an RCT in Severe hypertension in pregnancy (n=78). Oral nifedipine vs. Intravenous hydralazine 10 mg every 30 min up to 5 doses was evaluated on Number of doses needed to achieve targeted BP (p=0.008). Oral nifedipine required fewer doses to achieve targeted blood pressure compared to intravenous hydralazine (1.4 vs 1.7 doses, P=0.008) in pregnant women with severe hypertension.
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