Why the study?
Does hydralazine improve outcomes compared to other antihypertensives in women with severe hypertension in pregnancy?
Population
21 randomised controlled trials pooling 893 women with severe hypertension in pregnancy
Comparison
Hydralazine vs Other short-acting antihypertensives
Design
Meta-analysis
Authors
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Supports preferring other antihypertensives over hydralazine in severe pregnancy hypertension; challenges its historical first-line status.
Does hydralazine improve outcomes compared to other antihypertensives in women with severe hypertension in pregnancy?
Hydralazine is associated with worse maternal and fetal adverse outcomes compared to other antihypertensives for severe hypertension in pregnancy, challenging its historical use as a first-line agent.
Laura A. Magee (2003) studied this question.
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