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May 1, 1994BJOG An International Journal of Obstetrics & Gynaecology

Hydralazine boluses for the treatment of severe hypertension in pre‐eclampsia

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Why the study?

Does intravenous bolus hydralazine reduce mean arterial pressure in women with severe pre-eclampsia?

Population

70 consecutive women with severe pre-eclampsia and sustained severe hypertension

Design

Cohort

Authors

SPS Paterson-BrownNHS LothianSRStephen C. RobsonAustralian National UniversityNRNancy RedfernNewcastle upon Tyne Hospitals NHS Foundation Trust

Discussion

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Implication

Hydralazine boluses were associated with MAP reductions in severe pre-eclampsia; leaves open efficacy and safety versus randomized controls.

Structured PICO

Does intravenous bolus hydralazine reduce mean arterial pressure in women with severe pre-eclampsia?

P
Population
70 consecutive women with severe pre-eclampsia and sustained severe hypertension (accounting for 109 treatment episodes)
I
Intervention
Intravenous bolus hydralazine 5 mg, repeated every 15 min to reduce the mean arterial pressure to < 125 mmHg
O
Outcome
Change in mean arterial pressure in response to bolus hydralazine, fetal condition (assessed by heart rate changes and umbilical arterial pH at delivery), and protocol violationssurrogate

Intravenous hydralazine in 5 mg boluses is a safe and effective method for acutely lowering blood pressure in severe pre-eclampsia, though protocol adherence in clinical practice remains a challenge.

Limitations

  • Protocol violations were common (occurred in 25% of episodes)

Cite This Study

Paterson-Brown et al. (1994) studied this question.

synapsesocial.com/papers/6a703209febe604dd708fac2https://doi.org/10.1111/j.1471-0528.1994.tb11913.x

Topics

Hypertension management
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Blood Pressure Values in Parturients1991 · 5 citations
  2. 2Haemodynamic changes in gestational proteinuric hypertension: the effects of rapid volume expansion and vasodilator therapy1989 · 66 citations
  3. 3Intravenous Labetalol and Intravenous Dihydralazine in Severe Hypertension in Pregnancy1982 · 65 citations