Why the study?
Does a combination of propranolol and hydralazine improve blood pressure control and prevent complications in pregnant patients with longstanding hypertension?
Does a combination of propranolol and hydralazine improve blood pressure control and prevent complications in pregnant patients with longstanding hypertension?
The combination of propranolol and hydralazine provided good blood pressure control and favorable pregnancy outcomes in patients with essential hypertension, with minimal neonatal complications.
Should not yet change practice in hypertensive pregnancies; leaves open whether propranolol-hydralazine improves outcomes versus standard care.
A combination of propranolol and hydrallazine was administered to 13 patients with longstanding hypertension during 15 pregnancies. Hydrallazine was continued through labour and delivery in all patients, while in eight patients propranolol was discontinued 2 to 15 days before delivery. Blood pressure control was uniformly good and superimposed pre-eclampsia did not occur during combined therapy. There were 14 livebirths and one unexplained stillbirth. Except for two cases of milk hypoglycemia, there were no neonatal complications.
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Bott-Kanner et al. (1980) studied this question.
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