Key result
The ISTH-BAT bleeding score detected type I von Willebrand disease with excellent accuracy (AUC 0.989, sensitivity 96%, specificity 100%, P<0.001).
Why the study?
The study was conducted to evaluate bleeding score in Egyptian patients with type I von Willebrand disease and correlate it with laboratory parameters.
Does the ISTH-BAT questionnaire accurately detect type I von Willebrand disease and correlate with laboratory parameters?
Cross-Sectional (n=100)
No
Does the ISTH-BAT questionnaire accurately detect type I von Willebrand disease and correlate with laboratory parameters?
Effect estimate: AUC 0.989
p-value: p=<0.001
The ISTH-BAT questionnaire is a highly sensitive and specific tool for detecting type I von Willebrand disease.
ISTH-BAT demonstrates high accuracy for type 1 VWD detection in this Egyptian cohort; extends prior validation but leaves broader applicability open.
Background In the recent decade, bleeding evaluation methods have evolved to standardize the severity of bleeding symptoms in a uniform manner. In 2010, the International Society on Thrombosis and Hemostasis-Bleeding Assessment Tool (ISTH-BAT) was developed and validated. Aim and objectives The aim of the study was to evaluate bleeding score (BS) in Egyptian patients with von Willebrand disease (VWD) type I and correlate it with laboratory parameters. Patients and methods This cross-sectional cohort study was conducted at Assiut University Hospital. It included 100 participants that were divided into 49 patients with type I VWD and 51 healthy participants with no known problem with bleeding or bruising. The duration of the study was ~12 months. Results Study revealed that there was significant relation between BS severity and laboratory parameters such as level of von Willebrand factor: Ag ( P =0.02) while there was no significant relation between BS and sex ( P =0.390). By using receiver operating characteristic curve analysis, ISTH-BAT BS can detect type I VWD patients in total with excellent accuracy (98%), area under the curve was 0.989 with sensitivity and specificity of 96 and 100%, respectively ( P <0.001). Conclusion The ISTH-BAT BS is designed to reflect the severity of bleeding. Our results demonstrate the inherent variability of this bleeding pattern. We also found that the ISTH-BAT BS has high sensitivity and specificity to detect type I VWD patients in total with excellent accuracy.
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Hafez et al. (2023) conducted a cross-sectional in von Willebrand disease (VWD) type I (n=100). ISTH-BAT questionnaire vs. Healthy participants was evaluated on Detection of type I VWD patients (AUC 0.989, p=<0.001). The ISTH-BAT bleeding score detected type I von Willebrand disease with excellent accuracy (AUC 0.989, sensitivity 96%, specificity 100%, P<0.001).
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