Key result
Transcriptional analysis of the multigene family 110 of African swine fever virus revealed that four genes are actively transcribed until DNA replication, while the L270 gene is silenced earlier.
Population
African swine fever virus genome (multigene family 110) and infected Vero cells
Design
Preclinical
Authors
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L270 timing in ASFV informs early gene regulation studies; leaves open functional validation and antiviral potential in swine models.
This study provides the first detailed transcriptional map of a region of the African swine fever virus genome, identifying the L270 gene as an immediate early gene.
Almazán et al. (1992) studied African swine fever virus infection. African swine fever virus (ASFV) strain BA71V vs. Mock-infected Vero cells was evaluated on Transcriptional mapping of multigene family 110. Transcriptional analysis of the multigene family 110 of African swine fever virus revealed that four genes are actively transcribed until DNA replication, while the L270 gene is silenced earlier.
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