Key result
Ultrastructural evaluation of myocardial biopsies demonstrated significant progression of myocardial damage from Chagas' disease stage IA (13.0%) to stage II (25.5%), with the sarcoplasmic reticulum being the most affected organelle.
Population
72 patients, comprising 11 normal controls, 2 with acute Chagas' disease, and 61 with chronic Chagas' disease.
Design
Cross-sectional, Clinical histories were initially unknown to the examiner
Authors
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Progressive ultrastructural damage across Chagas stages is hypothesis-generating; prospective studies needed before informing staging or management.
Cross-Sectional (n=74)
Single-blind
Absolute Event Rate: 25.5% vs 10%
Ultrastructural analysis of myocardial biopsies reveals progressive subcellular damage across the clinical stages of Chagasic myocarditis, with the sarcoplasmic reticulum being the most affected organelle.
Palacios‐Prü et al. (1989) conducted a cross-sectional in Chagasic myocarditis (n=74). Chagas' disease stage vs. Normal controls was evaluated on Ultrastructural myocardial damage score (percentage of maximal theoretical abnormality). Ultrastructural evaluation of myocardial biopsies demonstrated significant progression of myocardial damage from Chagas' disease stage IA (13.0%) to stage II (25.5%), with the sarcoplasmic reticulum being the most affected organelle.
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