Key result
This review summarizes existing approaches to verifying metabolic phenotypes of obesity and their association with cardiovascular disease and mortality risk.
Why the study?
The expediency of separating obesity phenotypes and the very existence of metabolically healthy obesity in relation to cardiovascular risk remain widely debated.
This review discusses the verification, epidemiology, and cardiovascular risk associated with metabolically healthy versus unhealthy obesity phenotypes.
Answers are grounded in this paper and cite their sources.
Heterogeneity of obesity phenotypes may refine CV risk assessment; leaves open whether metabolically healthy obesity alters management.
Obesity is associated with numerous metabolic disorders, the development and progression of a wide range of conditions and diseases, primarily cardiovascular disease and type 2 diabetes. One of the widely discussed phenomena of the association of obesity with cardiovascular diseases, their complications and mortality is the phenomenon of “heterogeneity of obesity phenotypes in relation to cardiovascular risk”. Currently, two main phenotypes have been identified — metabolically healthy and metabolically unhealthy obesity. At the same time, not only the expediency of separation, but also the existence of this phenotype is widely discussed today. The article provides an overview of existing approaches to the verification of metabolic phenotypes of obesity and data relating to the epidemiology and the association of metabolically healthy obesity with the risk of cardiovascular diseases and death, and also discusses the factors that determine the features of the obesity phenotype.
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Druzhilov et al. (2019) conducted a review in Obesity. Metabolic phenotypes of obesity (metabolically healthy vs unhealthy) was evaluated. This review summarizes existing approaches to verifying metabolic phenotypes of obesity and their association with cardiovascular disease and mortality risk.
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