Key result
Prior successful percutaneous coronary intervention did not significantly increase the risk of early or late adverse outcomes after subsequent CABG, including 1-year cardiac mortality (P=0.25).
Why the study?
Does prior successful PCI increase hospital and early morbidity and mortality after subsequent CABG in patients requiring myocardial revascularization?
Cohort (n=1,254)
Does prior successful PCI increase hospital and early morbidity and mortality after subsequent CABG in patients requiring myocardial revascularization?
Previous successful PCI does not appear to increase the risk of early or late adverse outcomes, including mortality and morbidity, after subsequent CABG.
Answers are grounded in this paper and cite their sources.
Reassures on CABG safety after prior successful PCI; leaves open causal effects in randomized settings.
This study examines the influence of a successful PCI upon preoperative patient profile, peroperative management and postoperative, including one-year follow-up, results. From January 1999 through December 2001, 1141 patients (91%) underwent coronary artery bypass grafting (CABG) as the primary intervention for myocardial revascularization (group A) and 113 patients (9%) underwent primary CABG after an initially successful PCI (group B). Patients undergoing CABG after a failed PCI were not included. Patients in group B were statistically significant younger (P=0.010), with more peripheral arterial vascular (P=0.015) and renal disease (P=0.036). Left main coronary artery stenosis was significantly lower in group B (P=0.004). The number of diseased vessels did not differ between the two groups. However, less distal anastomoses were performed in group B (P=0.001). Postoperatively there was no statistically significant differences, in the percentages of myocardial infarction, arrhythmias, reinterventions, neurological, renal and pulmonary complications, and hospital mortality. One-year follow-up did not show any statistically significant differences in cardiac related mortality (P=0.25) or recurrent ischemic events (P=0.27). Multivariate analysis did not identify a successful PCI as a risk factor for early and late adverse outcomes. Previous PCI does not seem to result in a higher postoperative mortality or morbidity after CABG.
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Judith M.D. van den Brule (2005) conducted a cohort in Coronary artery disease requiring CABG (n=1,254). Initially successful PCI prior to CABG vs. CABG as primary intervention (no prior PCI) was evaluated on Cardiac related mortality at one year (p=0.25). Prior successful percutaneous coronary intervention did not significantly increase the risk of early or late adverse outcomes after subsequent CABG, including 1-year cardiac mortality (P=0.25).
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