Key result
Orally administered reviparin sodium produced a dose-dependent reduction in thrombosis incidence and was recovered from endothelium and plasma in a rat model.
Why the study?
Does orally administered reviparin sodium reduce thrombosis incidence in a rat model?
Population
Rat model of thrombosis (induced by 10% formalin in methanol to the exposed jugular vein), 20 rats/group
Design
Preclinical
Follow-up
Up to 8 hours
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Does not support clinical use; leaves open translation of oral heparin antithrombotic activity to humans.
Does orally administered reviparin sodium reduce thrombosis incidence in a rat model?
Orally administered reviparin sodium is absorbed and demonstrates dose-dependent antithrombotic activity in a rat model.
A 2001 study studied Thrombosis. Oral reviparin sodium was evaluated on Thrombosis incidence. Orally administered reviparin sodium produced a dose-dependent reduction in thrombosis incidence and was recovered from endothelium and plasma in a rat model.
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