Straightforward Synthesis of All Stenusine and Norstenusine Stereoisomers

This is the authors' abstract. We don't add key points for this paper.

All the stereoisomers of stenusine (1) and norstenusine (21) have been efficiently synthesized by the asymmetric hydrogenation of pyridines. The (2R,3S)‐ and (2R,3R)‐isomers of 1, that are difficult to prepare, have been synthesized for the first time using a chemoenzymatic approach in eight steps with an 8 % total yield. All the target compounds were obtained in good stereochemical purity by using very simple and inexpensive reagents and auxiliaries.