Key result
In patients with infantile spasms not treated with hormonal drugs, the cumulative spontaneous remission rate at 12 months was 25%, and 9% had normal development or mild impairment at long-term follow-up.
Population
44 patients with infantile spasms not treated with hormonal drugs
Design
Cohort
Follow-up
average age at follow-up 80 months
Authors
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This study provides baseline data on the natural history of untreated infantile spasms, showing a 25% spontaneous remission rate at 12 months, which is useful for designing therapeutic trials.
Cohort (n=44)
This study provides baseline data on the natural history of untreated infantile spasms, showing a 25% spontaneous remission rate at 12 months, which is useful for designing therapeutic trials.
Hrachovy et al. (1991) conducted a cohort in Infantile spasms (n=44). Non-hormonal treatment (spontaneous course) was evaluated on Cumulative spontaneous remission rate at 12 months. In patients with infantile spasms not treated with hormonal drugs, the cumulative spontaneous remission rate at 12 months was 25%, and 9% had normal development or mild impairment at long-term follow-up.
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