Key result
A coronary flow reserve value of 1.85 accurately predicted death in asymptomatic patients with moderate or severe aortic stenosis (AUC 0.890; 95% CI 0.287-0.946; P=0.009).
Why the study?
Does coronary flow reserve measurement predict death in asymptomatic patients with moderate or severe aortic stenosis, preserved ejection fraction, and nonobstructed coronary arteries?
Population
127 asymptomatic patients with moderate or severe aortic stenosis, preserved ejection fraction, and…
Design
Cohort
Follow-up
median 32 ± 7 months
Authors
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May support CFR-based risk stratification in asymptomatic aortic stenosis; hypothesis-generating and requires prospective validation.
Cohort (n=127)
Does coronary flow reserve measurement predict death in asymptomatic patients with moderate or severe aortic stenosis, preserved ejection fraction, and nonobstructed coronary arteries?
Effect estimate: AUC 0.890 (95% CI 0.287-0.946)
p-value: p=0.009
Coronary flow reserve is a strong independent predictor of mortality in asymptomatic patients with moderate to severe aortic stenosis and nonobstructed coronary arteries.
Banović et al. (2013) conducted a cohort in Asymptomatic moderate or severe aortic stenosis with preserved ejection fraction and nonobstructed coronary arteries (n=127). Coronary flow reserve (CFR) was evaluated on Death during mid-to-long-term follow-up (AUC 0.890, 95% CI 0.287-0.946, p=0.009). A coronary flow reserve value of 1.85 accurately predicted death in asymptomatic patients with moderate or severe aortic stenosis (AUC 0.890; 95% CI 0.287-0.946; P=0.009).
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