Key result
Administration of argatroban successfully prolonged aPTT from 39 to 57 seconds in a patient with acute myocardial infarction who developed repetitive stent thrombosis and heparin resistance.
Population
A 59-year-old woman with acute anterior myocardial infarction, uncontrolled diabetes mellitus, hypertension…
Design
Case_report
Follow-up
1 month
Authors
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Supports argatroban in heparin-resistant AMI stent thrombosis; hypothesis-generating and should not yet change practice.
Case Report (n=1)
No
Transient decreases in antithrombin III activity can occur in the acute phase of myocardial infarction, leading to heparin resistance and stent thrombosis, which may require alternative anticoagulation with a direct thrombin inhibitor like argatroban.
Kaku et al. (2009) conducted a case report in Acute Myocardial Infarction with Repetitive Stent Thrombosis and Heparin Resistance (n=1). Argatroban was evaluated on Prolongation of aPTT. Administration of argatroban successfully prolonged aPTT from 39 to 57 seconds in a patient with acute myocardial infarction who developed repetitive stent thrombosis and heparin resistance.
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