Key result
RVF in CTEPH is linked to a reversible ~20% reduction in LV free wall mass.
Why the study?
LV unloading in CTEPH may cause atrophic remodeling, prompting investigation into whether RVF from CTEPH reduces LV mass through atrophy.
Is right ventricular failure in CTEPH associated with reduced left ventricular mass, and is this reversible with pulmonary endarterectomy?
Population
36 consecutive CTEPH patients and 11 age- and sex-matched healthy volunteers
Comparison
CTEPH patients before vs after PEA, compared with healthy volunteers and a rat RVF model
Design
Observational cohort study and animal model
Authors
Loading...
Suggests ventricular interdependence in CTEPH RV failure; hypothesis-generating for LV mass as reversibility marker post-PEA.
Observational (n=47)
Is right ventricular failure in CTEPH associated with reduced left ventricular mass, and is this reversible with pulmonary endarterectomy?
Absolute Event Rate: 35% vs 44%
p-value: p=0.007
Right ventricular failure in CTEPH is associated with a reversible reduction in left ventricular mass due to atrophic remodeling, which improves following pulmonary endarterectomy.
Hardziyenka et al. (2011) conducted an observational in Chronic thromboembolic pulmonary hypertension (CTEPH) with right ventricular failure (n=47). Right ventricular failure vs. Patients without right ventricular failure was evaluated on Left ventricular free wall mass index (p=0.007). Right ventricular failure in patients with CTEPH is associated with a reversible reduction in LV free wall mass index compared to those without RVF (35 vs 44 g/m2, p=0.007).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: