Key result
Treatment with anti-IL 2R monoclonal antibody ART-18 or cyclosporin prolonged rat cardiac allograft survival compared to untreated rats, which rejected grafts within 7 days.
Why the study?
Does anti-IL 2R monoclonal antibody or cyclosporin improve graft survival and reduce cellular infiltration in a rat cardiac allograft model?
Population
Rat heterotopic cardiac allograft model
Comparison
Mouse anti-rat IL 2 receptor monoclonal antibody… vs Untreated rats
Design
Preclinical
Follow-up
Up to 22 days or indefinitely
Authors
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Findings limited to rat models; leaves open translation of IL-2R blockade to human transplant immunosuppression.
Does anti-IL 2R monoclonal antibody or cyclosporin improve graft survival and reduce cellular infiltration in a rat cardiac allograft model?
Cyclosporin and anti-IL 2R therapy inhibit in situ activation of T cells and macrophages and prolong graft survival in a rat cardiac allograft model.
Hancock et al. (1987) studied Acute rejection of rat heterotopic cardiac allografts. Anti-IL 2R monoclonal antibody ART-18 or cyclosporin (CsA) vs. Untreated rats was evaluated on Graft survival / rejection time. Treatment with anti-IL 2R monoclonal antibody ART-18 or cyclosporin prolonged rat cardiac allograft survival compared to untreated rats, which rejected grafts within 7 days.