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October 25, 2013The Thoracic and Cardiovascular Surgeon

Impact of Smoking Status on Outcomes after Concomitant Aortic Valve Replacement and Coronary Artery Bypass Graft Surgery

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Key result

Previous smoking was associated with increased late mortality compared with never smoking after concomitant AVR-CABG surgery (HR 1.44; 95% CI 1.14-1.81; p=0.002).

Why the study?

Does smoking status impact short-term complications and long-term mortality in patients undergoing concomitant AVR-CABG surgery?

Population

2,558 patients undergoing concomitant aortic valve replacement and coronary artery bypass graft surgery

Comparison

Current or previous smoking status vs Nonsmokers

Design

Cohort

Follow-up

mean 36 months (range, 0-105 months)

Authors

ASAkshat SaxenaLSLeonard ShanDDDiem Dinh

Discussion

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Member takes

Overview

Previous smoking history signals higher late mortality after AVR-CABG; leaves open whether cessation interventions improve survival in prospective studies.

Study Design

Type

Cohort (n=2,558)

Multicenter

Yes

Structured PICO

Does smoking status impact short-term complications and long-term mortality in patients undergoing concomitant AVR-CABG surgery?

P
Population
2,558 patients undergoing concomitant aortic valve replacement and coronary artery bypass graft surgery, followed for a mean of 36 months.
E
Exposure
Current or previous smoking status
C
Comparator
Nonsmokers
O
Outcome
14 short-term complications and long-term mortalityhard clinical

Main Result

Hazard Ratio: 1.44 (95% CI 1.14–1.81)

p-value: p=0.002

Smoking status does not significantly impact short-term perioperative outcomes after concomitant AVR-CABG, but previous smoking is associated with increased late mortality.

Cite This Study

Saxena et al. (2013) conducted a cohort in Concomitant aortic valve replacement and coronary artery bypass graft (AVR-CABG) surgery (n=2,558). Smoking status (previous or current smoking) vs. Nonsmokers was evaluated on Late mortality (HR 1.44, 95% CI 1.14-1.81, p=0.002). Previous smoking was associated with increased late mortality compared with never smoking after concomitant AVR-CABG surgery (HR 1.44; 95% CI 1.14-1.81; p=0.002).

synapsesocial.com/papers/6aa028a43dfbbd0b17e62953https://doi.org/10.1055/s-0033-1357083
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Current smoking predicts increased operative mortality and morbidity after cardiac surgery in the elderly☆2010 · 49 citations
  2. 2Predictors of mortality after aortic valve replacement2007 · 172 citations
  3. 3Coronary Artery Bypass Grafting Combined with Aortic Valve Replacement in Healthy Octogenarians does not Increase Postoperative Risk2002 · 21 citations
  4. 4EuroSCORE Predicts Short‐ and Mid‐Term Mortality in Combined Aortic Valve Replacement and Coronary Artery Bypass Patients2009 · 48 citations