Key result
Attenuation of Marek's disease virus is associated with the disappearance of a 1.8-kilobase transcript and the concomitant production of a truncated 0.4-kilobase RNA.
Authors
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Transcript changes may mark MDV attenuation; leaves open mechanistic validation and vaccine utility.
Bradley et al. (1989) studied Marek's disease virus (MDV) infection. Attenuated MDV vs. Pathogenic MDV was evaluated on RNA transcription within BamHI-H. Attenuation of Marek's disease virus is associated with the disappearance of a 1.8-kilobase transcript and the concomitant production of a truncated 0.4-kilobase RNA.
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