Key result
The presence of reticuloendotheliosis virus in the inoculum drastically reduced the humoral immune response to HVT, suggesting minor contaminations can markedly reduce Marek's disease vaccine efficacy.
Population
Chicken embryo fibroblast (CEF) cultures and chickens
Design
Preclinical
Follow-up
3 weeks
Authors
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Contamination may compromise Marek's disease vaccine efficacy in poultry; hypothesis-generating for enhanced quality control in avian vaccine production.
Contamination with reticuloendotheliosis virus drastically reduces the humoral immune response to Marek's disease vaccines in chickens.
V. v. Bülow (1977) studied Reticuloendotheliosis virus infection / Marek's disease vaccine contamination. Reticuloendotheliosis virus (REV) inoculation was evaluated on Humoral immune response to HVT. The presence of reticuloendotheliosis virus in the inoculum drastically reduced the humoral immune response to HVT, suggesting minor contaminations can markedly reduce Marek's disease vaccine efficacy.
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