Key result
The combination of ketamine and propofol was safe and effective for short gynecological procedures, maintaining hemodynamic stability with minimal adverse events including 4% nausea and vomiting and 2% apnea.
Why the study?
Patients undergoing operative procedures frequently experience pain and anxiety, making the choice of anesthesia for induction critical. This study examined the safety and effectiveness of combining ketamine and propofol for short procedures.
Does a ketamine and propofol combination provide safe and effective sedation and analgesia in adult patients undergoing short gynecological procedures?
Observational (n=50)
No
Does a ketamine and propofol combination provide safe and effective sedation and analgesia in adult patients undergoing short gynecological procedures?
The combination of ketamine and propofol provides safe and effective sedation with stable hemodynamics and minimal adverse effects for short gynecological procedures.
May support ketofol for short gynecologic procedures in anxious patients; leaves open efficacy confirmation in randomized trials.
Background: Patients who attend the hospital for any form of operative procedure frequently undergo physical or mental pain and agitation. These patients are extremely anxious. It is important to choose the most appropriate form of anesthesia for induction for the analgesia or sedation. This study examined the safety and effectiveness of the Ketamine and Propofol combination technique for short procedures like D and C, MTP, evacuation and marsupilisation of Bartholin’s abscess.Methods: The present observational study was carried out in association with the Gynecology and Obstetrics department and Department of Anesthesiology of PDMMC and hospital, Amravati, Maharashtra, India over a period of 3 months from 1st January to 31st March 2019.Results: In present study, 28 (56%) patients were of 25-40 years age, 14 (28%) patients were of 41-50 years age while 8 (16%) patients were of 51-60 years age. 7 (14%) patients were underweight, 26 (52%) patients had normal BMI, 10 (20%) patients were overweight while 7 (14%) patients were obese. MAP before surgery was 100 ± 12, which decreased to 92±9.2 during operation and increased to 97±19.4 in the postoperative period. Heart rate and arterial SPO2 were not significantly different before, during, and after the operation. Mean VAS score for pain was 5.2±5.1 and the mean Ramsay’s score of sedation was 5.8 ± 0.01. 1 (2%) patient had apnea, 1 (2%) patient had skin reaction, 1 (2%) patient had cough, 1 (2%) patient had agitation while 2 (4%) patient had nausea and vomiting.Conclusions: Ketamine and Propofol combination technique can be recommended for use in the short procedures safely and effectively.
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Patil et al. (2019) conducted an observational in Short gynecological procedures (D and C, MTP, evacuation and marsupilisation of Bartholin's abscess) (n=50). Ketamine and Propofol combination was evaluated on Adverse events. The combination of ketamine and propofol was safe and effective for short gynecological procedures, maintaining hemodynamic stability with minimal adverse events including 4% nausea and vomiting and 2% apnea.
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