Why the study?
Does prednisone treatment affect platelet function tests in patients with collagen or haematological diseases?
Observational (n=22)
Does prednisone treatment affect platelet function tests in patients with collagen or haematological diseases?
A 6-week treatment with commonly used doses of prednisone does not significantly affect platelet function in patients with collagen or hematological diseases.
Prednisone need not alter platelet function monitoring in these patients; leaves open confirmation in larger randomized cohorts.
Ivy bleeding time, capillary fragility, threshold ADP concentration for secondary platelet aggregation and platelet adhesiveness were found to be unchanged by 2 d and 6 weeks of treatment with prednisone in 22 consecutive patients with collagen or haematological diseases. Initial high platelet counts were unchanged after 2 d of treatment, but fell significantly to normal values after 6 weeks of treatment. Initial high levels of factor Vlll‐related antigen increased insignificantly following 2 d of treatment, but after 6 weeks of treatment the increase was significant. It is concluded that in patients of this category a 6‐week treatment with commonly used doses of prednisone does not significantly affect platelet function.
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Jørgensen et al. (1982) conducted an observational in Collagen or haematological diseases (n=22). Prednisone was evaluated on Platelet function (Ivy bleeding time, capillary fragility, threshold ADP concentration for secondary platelet aggregation, and platelet adhesiveness).
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