Key result
Vincristine transiently drops then moderately increases platelet counts in dogs without affecting bleeding time.
Why the study?
The effects of vincristine sulfate and prednisone on platelet numbers and function in clinically normal dogs were not fully characterized.
Does vincristine affect platelet numbers and function in clinically normal dogs?
Population
16 clinically normal dogs
Comparison
Single iv vincristine sulfate dose vs iv saline solution; with and without daily oral prednisone
Design
Preclinical study with comparison to previous control study
Follow-up
2 weeks
Authors
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Vincristine transiently raises platelet counts with minimal functional change in healthy dogs; leaves open its net benefit in thrombocytopenic patients.
Does vincristine affect platelet numbers and function in clinically normal dogs?
p-value: p=< 0.05
A single therapeutic dose of vincristine in normal dogs causes a transient decrease followed by a moderate increase in platelet numbers, without significantly affecting most platelet functions or bleeding time.
Mackin et al. (1995) studied Clinically normal dogs (n=16). Vincristine sulfate vs. Saline solution (iv) was evaluated on Circulating platelet numbers (p=< 0.05). Vincristine significantly affected circulating platelet numbers in normal dogs (P<0.05), causing a transient decrease then a moderate increase, without affecting clot retraction or bleeding time.
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