Why the study?
Does vincristine impair platelet aggregation in dogs with lymphoma?
Population
7 dogs with spontaneously occurring lymphoma
Comparison
Vincristine 0.5 mg/m2 vs Baseline (before administration of vincristine)
Design
Preclinical
Authors
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May increase bleeding risk in vincristine-treated dogs with lymphoma; hypothesis-generating and requires prospective validation before practice change.
Does vincristine impair platelet aggregation in dogs with lymphoma?
Vincristine administration significantly impairs platelet aggregation in dogs with lymphoma.
Grau-Bassas et al. (2000) studied this question.
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