Key result
5-HT activates both smooth muscle 5-HT7 receptors to produce relaxation and 5-HT2A receptors to produce contraction in the rabbit jugular vein, with the contraction masked by the relaxation.
In the rabbit jugular vein, 5-HT induces both relaxation via 5-HT7 receptors and contraction via 5-HT2A receptors, with the relaxing effect masking the contractile effect.
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Findings limited to rabbit veins and should not guide therapy; leaves open net 5-HT effects in human vessels with mixed receptor expression.
Itoh et al. (2011) studied this question. 5-HT was evaluated on Membrane potential and isometric tension. 5-HT activates both smooth muscle 5-HT7 receptors to produce relaxation and 5-HT2A receptors to produce contraction in the rabbit jugular vein, with the contraction masked by the relaxation.
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