Key result
Higher serum uric acid levels are significantly correlated with the severity of congestive heart failure and reduced left ventricular ejection fraction (r = 0.35, p < 0.001).
Why the study?
Whether hyperuricemia is an independent risk factor for heart failure or merely a consequence of associated cardiovascular disorders remains debatable, prompting investigation into its correlation with left ventricular ejection fraction.
Does serum uric acid level correlate with left ventricular ejection fraction and severity of congestive heart failure?
Observational (n=150)
No
Does serum uric acid level correlate with left ventricular ejection fraction and severity of congestive heart failure?
Mean Difference: 2.88
Absolute Event Rate: 8.43% vs 5.55%
p-value: p=0.02
Higher serum uric acid levels are significantly correlated with reduced left ventricular ejection fraction and severity of congestive heart failure, suggesting it may be an independent risk factor.
May aid heart failure risk assessment; leaves open whether uric acid independently predicts outcomes or warrants intervention.
Background: One of the risk factors of congestive heart failure that still under investigations is hyperuricemia. It’s still debatable whether it’s an independent risk factor or it’s just a consequence of other disorders associated with cardiovascular diseases like hypertension, diabetes and dyslipidemia. Objective: The aim of our study is to elucidate whether in patients with heart failure serum uric acid level correlates with left ventricular ejection fraction supporting the possibility that the detection of progressive hyperuricemia in these patients may be an indicator of deteriorating cardiac function. Methods: We conducted a prospective study that included 124 studied patients and 26 apparently healthy persons at Coronary care unit and Internal Medicine Department at Sohag University Hospitals. Studied populations were classified into; * Group “I”: newly diagnosed heart failure, * Group “II”: decompensated heart failure on regular treatment, * Group “III”: decompensated heart failure but stopped their treatment from three months, Group “IV”: control group, healthy and age-matched subjects. We studied the association between left ventricular ejection fraction, the severity of congestive heart failure and the serum uric acid levels and the well-known conventional risk factors. Results: The main finding was the significantly higher mean serum uric acid levels in patients with congestive heart failure versus apparently healthy persons with “P value = 0.02”. When we adjusted the serum uric acid with other significant risk factors in the univariate analysis which were age, gender and smoking, serum uric acid was an independent risk factor “P value = 0.04”. There was a significant correlation between serum uric acid level and the severity of congestive heart failure “P value 0.35”. High rates of serum uric acid levels were recorded in patients with reduced ejection fraction. A uric acid level of 8.45 mg/dl was found to be the most appropriate cut-off point with the sensitivity 62% and the specificity 78.5%. Conclusion: Higher serum uric acid levels are significantly correlated with the severity of congestive heart failure and left ventricular ejection fraction. Serum uric acid is an independent risk factor for congestive heart failure.
No takes yet. Share an insight, caveat, or question.
Ezzat et al. (2019) conducted an observational in Congestive Heart Failure (n=150). Serum uric acid level vs. Healthy controls / Normal serum uric acid was evaluated on Mean serum uric acid level in patients with congestive heart failure versus healthy controls (p=0.02). Higher serum uric acid levels are significantly correlated with the severity of congestive heart failure and reduced left ventricular ejection fraction (r = 0.35, p < 0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: