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January 27, 2011Congestive Heart Failure

Serum Uric Acid Levels Correlate With Filling Pressures in Systolic Heart Failure

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Why the study?

Do serum uric acid levels correlate with filling pressures and clinical profiles in patients with systolic heart failure?

Population

50 patients with systolic heart failure, aged 44±15 years, 74.5% men, 73% ischemic cardiomyopathy, and 50…

Comparison

Measurement of serum uric acid levels vs Age- and sex-matched controls with normal EF

Design

Case-control

Authors

AAAhmad AminAin Shams UniversityFVFarveh VakilianMashhad University of Medical SciencesMMMajid MalekiInterventional Cardiology

Discussion

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Implication

Serum uric acid may indicate filling pressures in systolic HF; hypothesis-generating for noninvasive use, requiring prospective validation.

Structured PICO

Do serum uric acid levels correlate with filling pressures and clinical profiles in patients with systolic heart failure?

P
Population
50 patients with systolic heart failure (EF <35%), aged 44±15 years, 74.5% men, 73% ischemic cardiomyopathy, and 50 age- and sex-matched controls with normal EF. Total n=100.
I
Intervention
Measurement of serum uric acid levels
C
Comparator
Age- and sex-matched controls with normal EF
O
Outcome
Correlation of serum uric acid with hemodynamic indices (pulmonary arterial pressure [PAP], pulmonary capillary wedge pressure [PCWP], and cardiac index) and clinical signssurrogate

Elevated serum uric acid levels in patients with systolic heart failure correlate with elevated left ventricular filling pressures and impaired clinical profiles, suggesting its potential as a noninvasive indicator.

Cite This Study

Amin et al. (2011) studied this question.

synapsesocial.com/papers/6a89218946f665d098760cb1https://doi.org/10.1111/j.1751-7133.2010.00205.x
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Uric Acid and Survival in Chronic Heart Failure2003 · 589 citations
  2. 2Uric Acid Predicts Clinical Outcomes in Heart Failure2003 · 167 citations
  3. 3Uric acid and xanthine oxidase: future therapeutic targets in the prevention of cardiovascular disease?2006 · 167 citations