Key result
An 18-year-old woman died from refractory cardiac arrest and complete myocardial nonexcitability 20 hours after a suicidal overdose of propafenone and diazepam, despite extensive resuscitation.
Why the study?
Diazepam poisoning is common, but propafenone poisoning is relatively rare, and there were no reported cases of combined propafenone and diazepam poisoning.
Case Report (n=1)
No
This case highlights the lethal potential of combined propafenone and diazepam overdose, which can lead to refractory cardiac arrest and complete myocardial nonexcitability unresponsive to pacing.
First reported combined propafenone-diazepam overdose; leaves open optimal management strategies pending further evidence.
Background: Diazepam poisoning is a common emergency situation in internal medicine, but propafenone poisoning is rare relatively. At present, there is no reported case of propafenone poisoning combined with diazepam. Case presentation: An 18-year-old woman was admitted to our hospital with an overdose of oral propafenone and diazepam, who presented with convulsions and syncope. She was treated with cardiopulmonary resuscitation, rehydration, atropine, sodium bicarbonate, and vasopressors including dopamine，epinephrine, norepinephrine, isoproterenol, but sinus rhythm could not recovery and cardiac arrest occurred. Temporary pacemaker was implanted. However, even with multiple electrode positions, effective capture could not be achieved. The patient died eventually. Conclusion: This was the first reported case of propafenone poisoning combined with diazepam. We should be alert to the possibility of propafenone poisoning when we find similar situations in arrhythmia patients.
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Yan et al. (2023) conducted a case report in Propafenone and diazepam intoxication (n=1). Propafenone and diazepam overdose was evaluated on Clinical outcome. An 18-year-old woman died from refractory cardiac arrest and complete myocardial nonexcitability 20 hours after a suicidal overdose of propafenone and diazepam, despite extensive resuscitation.
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