Key result
In a patient with severe oral self-poisoning, initial toxic plasma concentrations of propafenone correlated positively with the widening of the QRS-complex.
Why the study?
Do plasma concentrations of propafenone correlate with electrocardiographic changes in severe poisoning?
Population
1 patient with severe oral self-poisoning of propafenone
Design
Case_report
Authors
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Supports QRS monitoring in propafenone overdose; leaves open whether plasma levels should guide therapy.
Case Report (n=1)
Do plasma concentrations of propafenone correlate with electrocardiographic changes in severe poisoning?
In severe propafenone poisoning, plasma concentrations correlate with QRS widening, and metabolic patterns suggest saturation of the CYP2D6 isoenzyme.
Fonck et al. (1998) conducted a case report in Severe oral self-poisoning with propafenone (n=1). Propafenone poisoning was evaluated on Correlation between plasma concentrations and electrocardiographic changes. In a patient with severe oral self-poisoning, initial toxic plasma concentrations of propafenone correlated positively with the widening of the QRS-complex.
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