Why the study?
Does chronic propafenone dosing lead to metabolite cumulation in patients with frequent ventricular ectopy?
Population
Patients with frequent ventricular ectopy
Design
Cohort
Follow-up
24 hours post-discontinuation
Authors
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Chronic propafenone may cause metabolite cumulation; hypothesis-generating for clinical effects in ventricular ectopy.
Does chronic propafenone dosing lead to metabolite cumulation in patients with frequent ventricular ectopy?
Propafenone metabolites 5-OHP and NDPP cumulate in the plasma during chronic oral therapy, suggesting a need to elucidate their clinical role.
Kates et al. (1985) studied this question.
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