Key result
Propafenone administration in patients with ventricular arrhythmias showed a terminal t1/2 of 5.0 +/- 3.6 hr, which increased to 6.2 +/- 3.3 hr after 5 days of oral dosing.
Why the study?
What are the disposition kinetics of propafenone after intravenous and oral administration in patients with ventricular arrhythmias?
What are the disposition kinetics of propafenone after intravenous and oral administration in patients with ventricular arrhythmias?
Propafenone exhibits considerable intersubject variability in disposition kinetics, with evidence suggesting that clearance decreases during chronic oral dosing.
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Suggests clearance may decline with chronic oral use; leaves open dosing optimization in ventricular arrhythmia patients.
Connolly et al. (1984) studied Ventricular arrhythmias. Propafenone was evaluated on Propafenone disposition kinetics (clearance, steady-state volume of distribution, and terminal t1/2). Propafenone administration in patients with ventricular arrhythmias showed a terminal t1/2 of 5.0 +/- 3.6 hr, which increased to 6.2 +/- 3.3 hr after 5 days of oral dosing.
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