Key result
Administration of inotropic agents (dopamine and dobutamine) successfully reversed severe bradycardia, hypotension, and electrocardiographic abnormalities in a 15-year-old female following a massive propafenone overdose.
Why the study?
Propafenone poisoning is rare but potentially life-threatening due to drug-induced arrhythmias, prompting the need to highlight lethal intoxication and present a therapeutic strategy based on close monitoring and cardiac output support.
Case Report (n=1)
Propafenone intoxication can cause life-threatening arrhythmias and seizures, which can be successfully managed with close monitoring and cardiac output support.
Supports recovery with monitoring in adolescent propafenone overdose; hypothesis-generating and leaves open need for systematic validation.
Propafenone is an antiarrhythmic agent for the management of ventricular and supraventricular tachycardia and atrial fibrillation. Propafenone poisoning is rare but may be life-threatening due to drug-induced arrhythmias. Electrocardiographic changes in PR, QRS, and QT intervals have been recorded. We present a case of a 15-year-old female adolescent who developed arrhythmias and convulsions due to propafenone intoxication, in an attempt to commit suicide. The outcome of the case was a full recovery from the arrhythmias and the seizures. The aim of this article is to highlight the possibility of a lethal intoxication by a common antiarrhythmic drug. Our case aims to present our therapeutic strategy that relies mainly on close monitoring of patients and cardiac output support.
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Keramari et al. (2021) conducted a case report in Propafenone poisoning (n=1). Inotropic agents (dopamine and dobutamine) was evaluated on Clinical and electrocardiographic recovery. Administration of inotropic agents (dopamine and dobutamine) successfully reversed severe bradycardia, hypotension, and electrocardiographic abnormalities in a 15-year-old female following a massive propafenone overdose.
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