Genetic Mapping of the Human X Chromosome: Linkage Analysis of the q26-q28 Region That Includes the Fragile X Locus and Isolation of Expressed Sequences

This is the authors' abstract. We don't add key points for this paper.

The X chromosome is probably the most studied of all human chromosomes, in part because more than 115 diseases show X-linked inheritance, because of the relative ease of linkage analysis, and because of the interest in diagnostic applications, since these diseases can appear in successive or collateral generations within a family. About 70 polymorphic DNA markers have been isolated and partially characterized as of August 1985, most of them corresponding to anonymous genomic sequences, and nine genes have been cloned (Goodfellow et al. 1985). The restriction-fragment-length polymorphism (RFLP) markers are being used to construct a genetic map of the whole chromosome (Drayna and White 1985), and many disease loci have already been placed on this map (Goodfellow et al. 1985). However, in most cases the genetic localizations are still imprecise, whereas for diagnostic applications in a given disease it is mandatory (when the gene has not been cloned) to have...