Key result
Among patients with clinically manifest atherosclerosis, women had a lower risk of the composite cardiovascular outcome compared to men (HR 0.73; 95% CI 0.60-0.87).
Why the study?
Does female sex improve long-term prognosis in patients with clinically manifest atherosclerosis compared to male sex?
Population
5349 patients with at least one type of atherosclerotic vascular disease, mean age 60 years.
Comparison
Female sex (observational comparison) vs Male sex (reference category)
Design
Cohort
Follow-up
median 5 years
Authors
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Supports sex-specific risk stratification in manifest atherosclerosis; leaves open whether associations are causal or treatment-related.
Cohort (n=5,349)
Does female sex improve long-term prognosis in patients with clinically manifest atherosclerosis compared to male sex?
Hazard Ratio: 0.73 (95% CI 0.6–0.87)
Women with clinically manifest atherosclerosis have a significantly better long-term prognosis regarding mortality and cardiovascular events compared to men.
Meer et al. (2012) conducted a cohort in clinically manifest atherosclerosis (n=5,349). Female sex vs. Male sex was evaluated on cardiovascular outcome (composite of myocardial infarction, stroke and cardiovascular death) (HR 0.73, 95% CI 0.60-0.87). Among patients with clinically manifest atherosclerosis, women had a lower risk of the composite cardiovascular outcome compared to men (HR 0.73; 95% CI 0.60-0.87).
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