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A series of substituted benzazocine acids (VIa–h) have been prepared by a one-carbon homologation procedure from the benzazocine-2,6-diones (IIa–f). A novel rearrangement of the intermediate aldehyde (Va) to 3,4-dihydrocarbazol-1(2H)-one was discovered. The anti-inflammatory activity of the acids (VIa–h) was investigated.
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Jones et al. (1975) studied this question.
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